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CTI Bibliography of Technical Papers - Legionnaires' Disease

Revised March 2008

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Legionnaires' Disease
Order Number Title Author Date
Concentration, Serotypic, Profiles and Infectivity of Legionnaires' Disease Bacteria Populations in Cooling Towers (TP-249A) R.L. Tyndall, Zoology Dept., University of Tennessee 1982
Abstract: The concentration and serotypic profiles of Legionnaires' Disease Bacteria (LDB) in water of industrial cooling towers from various areas of the continental United States was determined. The characteristics of the LDB populations were compared to the biocide treatment and type of tower fill. Effects of cleaning and altered biocide treatment on LDB populations were assessed. The ubiquity of the LDB in both ambient control and cooling tower water was demonstrated.
Microbicidal Efficacy of BNPD Against Legionella Pheumophila (TP-87-18) Michael Coghlin & Gary Caplan Bird Archer, Inc. 1987
Abstract: The veracity of in vitro biocide evaluations reviewed in the context of Legionella Pneumophila field study disinfections. In particular, a new nonoxidizing biocide is presented which appears to be uniquely effective in controlling populations of L.P. Efficacy of biocidal disinfections is discussed in terms of biomass penetration and mode of cellular destruction.
The Control of Bacteria on Surfaces: Effectiveness of Bromine-Based Biocides Towards Microbial Biofilms and Biofilm-Associated Legionella Pneumophila. Chris Nalepa, Eric Liimatta and Johnthan Howarth, Albemarle Corporation; H. Ceri and C.A. Stremick, The Biofilm Research Group and Janet Stout and Y. Eason Lin, VA Medical Center, Special Pathogens Laboratory 2002
Abstract: Proper cooling system operation depends on maintaining clean system surfaces for optimum heat transfer and system longevity. Biofilms or microbiological growth on surfaces can negatively impact the operation of cooling systems in many ways by impeding efficient heat transfer in heat exchangers, by clogging film fill surfaces, and by creating an environment for destructive and pathological organisms such as sulfate-reducing bacteria (SRBs) and Legionella pneumophila. For the past several years, we have studied the effectiveness of bromine-based biocides for control of biofilm bacteria in general and for control of problem organisms like Legionella pheumophila and SRBs in particular. This work indicates subtle differences in the activity of various bromine-biocides and provides guidance for the development of effective microbiological treatment strategies for industrial cooling systems.
A New Method to Measure Viable Legionella and Total Heterotrophic Aerobic Bacteria William F. McCoy, Phigenics LLC 2008
Abstract: A new field method for enumerating viable Legionella and total heterotrophic aerobic bacteria was evaluated in hundreds of laboratory experiments and from analysis of over two thousand field samplers used in actual operating conditions. The method has been proven reliable for determining viable cell concentrations of Legionella pneumophila, Legionella species and total heterotrophic aerobic bacteria. In comparison to standard methods, the new protocol has been shown to be more accurate, faster and more convenient. Comparisons to other rapid methods are presented. Guidance is given for use of the new method within the context of hazard analysis and control to prevent legionellosis.